Japanese Encephalitis Virus (JEV)
Structure and Key Research Targets
Japanese Encephalitis Virus (JEV) structure
Overview
Japanese encephalitis virus (JEV) is an enveloped, positive-sense single-stranded RNA virus belonging to the genus Flavivirus within the family Flaviviridae. JEV infection primarily affects the central nervous system and is an important model for studying flavivirus structure, viral replication, immune recognition, and antibody responses. The Envelope protein (E) is a major surface antigen involved in viral entry and neutralizing antibody recognition, making it a key target for JEV research.
JEV Structure
JEV is an approximately 40-50 nm enveloped virus containing an approximately 11 kb positive-sense single-stranded RNA genome. The viral surface is mainly composed of E and M proteins arranged on the lipid envelope. The E protein forms the outer protein shell and plays essential roles in receptor binding and membrane fusion during viral entry. The internal nucleocapsid contains viral RNA associated with the capsid protein, while non-structural proteins participate in viral RNA replication and polyprotein processing.
The viral genome encodes a single polyprotein that is processed into three structural proteins and seven non-structural proteins:
- Structural proteins: Capsid (C) protein, Premembrane/Membrane (prM/M) protein, Envelope (E) protein
- Non-structural proteins: NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5
Key Research Targets
Key Research Targets of Japanese Encephalitis Virus
| Target | Major Function | Research Applications |
|---|---|---|
| Envelope protein (E) | Viral attachment, membrane fusion, major neutralizing antigen | Antibody development, neutralization assays, vaccine research |
| prM/M protein | Viral maturation and particle formation | Structural biology and virion assembly studies |
| NS1 protein | Replication complex formation and immune response | Antigen detection and host-virus interaction studies |
| NS3 protein | Viral protease and helicase activity | Replication mechanism studies |
| NS5 protein | RNA polymerase and gene replication | Molecular virology and antiviral research |
AntibodySystem Japanese Encephalitis Virus Research Products
AntibodySystem provides research reagents supporting studies of viral antigen recognition, antibody responses, and molecular characterization of JEV.
JEV Antigens
| Cat. No. | Product Name |
|---|---|
| EVV25801 | Recombinant JEV NS1/Non-structural protein 1 Protein, C-Fc |
| YVV39801 | Recombinant JEV NS3/Serine protease NS3 Protein, N-His |
| YVV43201 | Recombinant JEV NS5 Protein, N-His |
| YVV43402 | Recombinant JEV Peptide pr Protein, N-GST & C-His |
JEV Antibodies
| Cat. No. | Product Name |
|---|---|
| VVV25701 | InVivoMAb Anti-JEV Envelope protein E Antibody (2F2) |
| PVV43301 | Anti-JEV Capsid protein C/Core protein Polyclonal Antibody |
| PVV25701 | Anti-JEV Envelope protein E Polyclonal Antibody |
| PVV25802 | Anti-JEV NS1/Non-structural protein 1 Polyclonal Antibody |
| PVV39801 | Anti-JEV NS3/Serine protease NS3 Polyclonal Antibody |
| PVV43201 | Anti-JEV NS5 Polyclonal Antibody |
| PVV43401 | Anti-JEV Peptide pr Polyclonal Antibody |
AntibodySystem — Reliable Reagents for JEV Research
AntibodySystem offers high-quality recombinant proteins and antibodies to support JEV antigen characterization, antibody screening, vaccine studies, and diagnostic assay development.
